The formula was created by Qian Yi as dihuang pill . It was published in "Xiao'er Yao Zheng Zhi Jue" in 1119 by Qian Yi's student.
The formula was changed slightly when it was borrowed as a Japanese kampo formula. Some species of herbs were replaced with herbs found in Japan. For example, ''Alisma plantago-aquatica'' was replaced with ''Alisma orientale'' for .